Alflutinib

SKU: orb1306046

Description

Alflutinib (Firmonertinib) is a small molecule EGFR inhibitor targeting both activating mutations and the T790M resistance mutation. It is used in research applications, including in vitro and in vivo studies, to investigate its antitumor efficacy in models of non-small cell lung cancer (NSCLC).

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1869057-83-9
• MW: 568.59
• Purity: 99.87%
• Formula: C₂₈H₃₁F₃N₈O₂
• SMILES: CN1C=C(C=2C1=CC=CC2)C3=NC(NC4=C(OCC(F)(F)F)N=C(N(CCN(C)C)C)C(NC(C=C)=O)=C4)=NC=C3
• Target: EGFR,Cytochromes P450
• Solubility: DMSO:10.83 mg/mL (19.05 mM)

Bioactivity

• Target IC50:
  EGFR:|CYP3A4:0.25 μM(EC50)(Cell-free assay)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYP3A4, Alflutinib, cancer, ASK 120067, ASK120067, ASK-120067, AST 2818, AST2818, AST-2818, esistant mutation, Furmonertinib, ErbB-1, Epidermal growth factor receptor, EGFR, Firmonertinib, Inhibitor, HER1, inhibit, NSCLC, T790M

Compound Identifiers

PubChem CID

118861389