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Alflutinib

SKU: orb1306046

Description

Alflutinib (Firmonertinib) is a small molecule EGFR inhibitor targeting both activating mutations and the T790M resistance mutation. It is used in research applications, including in vitro and in vivo studies, to investigate its antitumor efficacy in models of non-small cell lung cancer (NSCLC).

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number1869057-83-9
MW568.59
Purity99.87% (May vary between batches)
FormulaC28H31F3N8O2
SMILESCN1C=C(C=2C1=CC=CC2)C3=NC(NC4=C(OCC(F)(F)F)N=C(N(CCN(C)C)C)C(NC(C=C)=O)=C4)=NC=C3
TargetCytochromes P450,EGFR
SolubilityDMSO:10.83 mg/mL (19.05 mM)

Bioactivity

Target IC50
EGFR:|CYP3A4:0.25 μM(EC50)(Cell-free assay)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CYP3A4, Alflutinib, cancer, ASK 120067, ASK120067, ASK-120067, AST 2818, AST2818, AST-2818, esistant mutation, Furmonertinib, ErbB-1, Epidermal growth factor receptor, EGFR, Firmonertinib, Inhibitor, HER1, inhibit, NSCLC, T790M

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 100.00
5 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 210.00
10 mg
$ 240.00
25 mg
$ 440.00
50 mg
$ 640.00
100 mg
$ 830.00
200 mg
$ 1,160.00
DispatchUsually dispatched within 5-10 working days
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