AL 8697

SKU: orb1310012

Description

AL 8697 is a potent and selective p38α MAPK inhibitor, exhibiting significant selectivity over p38β and a broad kinase panel. Its anti-inflammatory properties support its use in research models investigating inflammatory pathways, both in cellular assays and in vivo studies.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1057394-06-5
• MW: 402.41
• Purity: 99.89% (May vary between batches)
• Formula: C₂₁H₂₁F₃N₄O
• SMILES: Cc1c(F)cc(cc1-c1c(F)cn2c(nnc2c1F)C(C)(C)C)C(=O)NC1CC1
• Target: p38 MAPK,Autophagy
• Solubility: DMSO:95 mg/mL (236.08 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (8.2 mM)

Bioactivity

• Target IC50:
  p38β:82 nM|p38α:6 nM
• In Vivo:
  In male Wistar rats, AL 8697 (1, 3, 10, 30 mg/kg; p.o.) decreases the oedema in right and left paws in a dose-dependent manner thereby causing a larger improvement in the contralateral un-injected paw.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AL8697, AL-8697, AL 8697, Autophagy, inhibit, p38MAPK, p38α, p38β, p38 MAPK, Inhibitor

Compound Identifiers

PubChem CID

25060093