AL 8697

SKU: orb1940830

Description

AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases. AL 8697 has anti-inflammatory activity.(In Vivo):In male Wistar rats, AL 8697 (1, 3, 10, 30 mg/kg; p.o.) decreases the oedema in right and left paws in a dose-dependent manner thereby causing a larger improvement in the contralateral un-injected paw.

Key Properties

• CAS Number: 1057394-06-5
• MW: 402.421
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₁F₃N₄O
• SMILES: Cc1c(F)cc(cc1-c1c(F)cn2c(nnc2c1F)C(C)(C)C)C(=O)NC1CC1
• Target: p38 MAPK
• Solubility: In Vitro: DMSO : 100 mg/mL (248.50 mM)

Bioactivity

• In Vivo:
  AL 8697 (1-30 mg/kg; p.o. ; once daily for 10 days) dose-dependently decreases the oedema in right and left paws. Animal model: Male Wistar rats. Dosage: 1, 3, 10, 30 mg/kg. Administration: Oral gavage; once daily for 10 days. Result: Dose-dependently decreased the oedema in right and left paws, causing a larger improvement in the contralateral un-injected paw.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

p38 MAPK