AK-1

SKU: orb1301647

Description

AK-1 is a SIRT2 inhibitor with an IC50 of 12.5 µM. It exhibits neuroprotective effects in Alzheimer's disease models by promoting tubulin acetylation and also induces cell cycle arrest in colon carcinoma cells in vitro.

Research Area

Epigenetics & Chromatin, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 330461-64-8
• MW: 403.45
• Purity: 98.00% (May vary between batches)
• Formula: C₁₉H₂₁N₃O₅S
• SMILES: [O-][N+](=O)c1cccc(NC(=O)c2cccc(c2)S(=O)(=O)N2CCCCCC2)c1
• Target: Sirtuin
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (4.96 mM);DMSO:40 mg/mL (99.14 mM)

Bioactivity

• Target IC50:
  SIRT2:12.5 μM
• In Vitro:
  AK-1 induces the formation of α-synuclein aggregates in H4 neuroglioma cells expressing α-synuclein and synphilin-1.AK-1 (5 μM) decreases total cholesterol levels in Neuro2a and primary rat striatal neurons, as well as in hippocampal slice cultures.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, AK1, AK-1, AK 1, SIRT2, Sirtuin

Compound Identifiers

PubChem CID

1341463