AK-1

SKU: orb1301647

Description

AK-1 is a SIRT2 inhibitor with an IC50 of 12.5 µM. It exhibits neuroprotective effects in Alzheimer's disease models by promoting tubulin acetylation and also induces cell cycle arrest in colon carcinoma cells in vitro.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 330461-64-8
• MW: 403.45
• Purity: 99.01%
• Formula: C₁₉H₂₁N₃O₅S
• SMILES: [O-][N+](=O)c1cccc(NC(=O)c2cccc(c2)S(=O)(=O)N2CCCCCC2)c1
• Target: Sirtuin
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (4.96 mM);DMSO:40 mg/mL (99.14 mM)

Bioactivity

• Target IC50:
  SIRT2:12.5 μM
• In Vitro:
  AK-1 induce the formation of α-synuclein aggregates in H4 neuroglioma cells expressing α-synuclein and synphilin-1.AK-1 (5 μM) decreases total cholesterol levels in Neuro2a and Primary rat striatal neurons, as well as in hippocampal slice culture.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, AK1, AK-1, AK 1, SIRT2, Sirtuin

Compound Identifiers

PubChem CID

1341463