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AHR antagonist 5

SKU: orb1710468

Description

AHR antagonist 5 (Example 39) is a potent, orally bioavailable aryl hydrocarbon receptor inhibitor with an IC50 below 0.5 µM. It demonstrates significant in vivo antitumor efficacy in combination with anti-PD-1 checkpoint blockade, making it a valuable research tool for immuno-oncology studies.

Research Area

Immunology & Inflammation

Images & Validation

Key Properties

CAS Number2247953-39-3
MW550.89
FormulaC25H27Cl3FN7
SMILESCl.Cl.Cl.CC(C)c1cnn2c(N[C@@H]3CCc4[nH]c5ccccc5c4C3)nc(nc12)-c1cncc(F)c1
TargetAryl Hydrocarbon Receptor,Others

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Key Properties

No computed properties available.

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AHR antagonist 5 (orb1710468)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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