Prochloraz

SKU: orb1306591

Description

Prochloraz is a contact imidazole fungicide that potently inhibits aromatase (IC50 = 40 nM) and acts as an antagonist for estrogen (IC50s = 25 μM) and androgen (IC50 = 4 μM) receptors while activating the aryl hydrocarbon receptor (EC50 = 1 μM). It is widely used in endocrine disruption research and in vitro toxicology studies to investigate steroidogenesis and receptor-mediated signaling pathways.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 67747-09-5
• MW: 376.67
• Purity: 99.79% (May vary between batches)
• Formula: C₁₅H₁₆Cl₃N₃O₂
• SMILES: C(N(CCOC1=C(Cl)C=C(Cl)C=C1Cl)CCC)(=O)N2C=CN=C2
• Target: Estrogen Receptor/ERR,AhR,Antifungal,Aryl Hydrocarbon Receptor,Androgen Receptor
• Solubility: DMSO:27.5 mg/mL (73.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.65 mM)

Bioactivity

• Target IC50:
  Antifungal:40 nM|ERR:25 μM|AhR:1 μM(EC50)|Androgen receptor:4 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AhR, androgen, Androgen Receptor, AndrogenReceptor, antifungal, Antifungal, aromatase,estrogen, aryl, Aryl Hydrocarbon Receptor, biosynthesis, BTS 40542, BTS40542, BTS-40542, imidazole, inhibit, Inhibitor, microsomal, Fungal, ergosterol, ERR, Estrogen Receptor, human, EstrogenReceptor, Estrogen Receptor/ERR, hydrocarbon, Sporgon, placenta, Prochloraz, Prelude

Compound Identifiers

PubChem CID

73665