AHR antagonist 5 free base

SKU: orb1691076

Description

This orally bioavailable small molecule is a potent AHR antagonist, demonstrating IC50 values of 35-150 nM across human and rodent cell lines. Its anticancer activity supports its use in vitro and in vivo for researching oncology, immunology, and toxicology pathways.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2247950-42-9
• MW: 441.5
• Purity: 99.88% (May vary between batches)
• Formula: C₂₅H₂₄FN₇
• SMILES: N(C=1N2C(=C(C(C)C)C=N2)N=C(N1)C=3C=C(F)C=NC3)[C@H]4CC=5C=6C(NC5CC4)=CC=CC6
• Target: Aryl Hydrocarbon Receptor
• Solubility: DMSO:50 mg/mL (113.25 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (5.66 mM)

Bioactivity

• In Vitro:
  AHR antagonist 5 free base induces an activated human T cell state and inhibits CYP1A1 and interleukin (IL)-22 gene expression. AHR antagonist 5 increases pro-inflammatory cytokines, such as IL-2 and IL-9.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AHR antagonist 5, AHR antagonist 5 free base, ArylHydrocarbonReceptor, Aryl Hydrocarbon Receptor, aryl hydrocarbon receptor

Compound Identifiers

PubChem CID

140944699