AH 6809

SKU: orb1218149

Description

AH 6809 is an antagonist of EP and DP receptor(with Kis of 1217, 1150, 1597, and 1415 nM for the cloned human EP1, EP2, EP3-III, and DP receptor respectively). AH 6809 has a Ki of 350 nM for mouse EP2 receptor.

Key Properties

• CAS Number: 33458-93-4
• MW: 298.29
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₄O₅
• SMILES: CC(C)Oc(cc1)cc(Oc(cc2)c3cc2C(O)=O)c1C3=O
• Target: Prostaglandin Receptor
• Solubility: DMSO:25 mg/mL (83.81 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)

Bioactivity

• In Vivo:
  AH 6809 (5 mg/kg; i.p.) decreases TsV-induced mortality, PGE2 and IL-1β production and neutrophil infiltration in the lungs of mice.
• In Vitro:
  AH 6809 (1 μM; 30 min) inhibits T. serrulatus venom (TsV)-induced and PGE2-amplified IL-1β and cAMP production in macrophages. AH 6809 (30-300 μM) antagonizes the anti-aggregatory activity of PGD2 in whole blood, with an apparent pA2 of 5.35.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Prostaglandin Receptor