AG1557

SKU: orb1306688

Description

AG1557 is a potent and selective EGFR tyrosine kinase inhibitor with a pIC50 of 8.194. This small molecule is used in biochemical and cellular assays to study EGFR-driven signaling pathways in cancer research, including investigations into cell proliferation and tumor growth.

Research Area

Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 189290-58-2
• MW: 407.21
• Purity: 99.23% (May vary between batches)
• Formula: C₁₆H₁₄IN₃O₂
• SMILES: COc1cc2ncnc(Nc3cccc(I)c3)c2cc1OC
• Target: EGFR,Potassium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.46 mM);DMSO:4.08 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  EGFR:8.194 (pIC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, EGFR, Epidermal growth factor receptor, ErbB-1, Inhibitor, HER1, hERG, AG 1557, AG1557, AG-1557

Compound Identifiers

PubChem CID

5328201