AG-825

SKU: orb1707709

Description

AG-825 (Tyrphostin C15) is a selective ErbB2/HER2 inhibitor with an IC50 of 0.35 µM, demonstrating anticancer activity in breast cancer xenograft models. It has also been investigated in neurotoxicity and Alzheimer's disease research, and shown to induce apoptosis in human neutrophils in vitro.

Research Area

Cardiovascular Research, Cell Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 149092-50-2
• MW: 397.47
• Purity: 99.52% (May vary between batches)
• Formula: C₁₉H₁₅N₃O₃S₂
• SMILES: COc1cc(\C=C(/C#N)C(N)=O)cc(CSc2nc3ccccc3s2)c1O
• Target: EGFR,Apoptosis,Adrenergic Receptor
• Solubility: 10% DMSO+90% Saline:3.3 mg/mL (8.3 mM);DMSO:200 mg/mL (503.18 mM)

Bioactivity

• Target IC50:
  EGFR:19 μM|ErbB2:0.35 μM

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, AG 825, AG825, AG-825, ErbB2, EGFR, Tyrphostin AG 825, Tyrphostin AG825, Tyrphostin AG-825

Compound Identifiers

PubChem CID

6091659