AG 555

SKU: orb1302949

Description

AG 555 (Tyrphostin B46) is a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It is utilized in biochemical and cellular research to study EGFR-driven signaling pathways and has been employed in both in vitro assays and in vivo models to investigate oncology and cell proliferation.

Research Area

Cardiovascular Research, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 133550-34-2
• MW: 322.36
• Purity: 100.00%
• Formula: C₁₉H₁₈N₂O₃
• SMILES: Oc1ccc(C=C(C#N)C(=O)NCCCc2ccccc2)cc1O
• Target: EGFR,Reverse Transcriptase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.2 mM);DMSO:40 mg/mL (124.08 mM)

Bioactivity

• Target IC50:
  EGFR:0.7 μM
• In Vitro:
  Cell incubation in the presence of 30 μM AG 555 results in a selective down-regulation of the most abundant viral transcripts already 4 h after drug application. AG55 inhibits the growth of HPV16-immortalized cells. AG555 is already effective at 10 μM (IC50=6.4, respectively), and the cells remain arrested after withdrawal of the compound on day 5 as monitored on days 8 and 12.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antiretroviral, BPV, Bovine, AG555, AG-555, AG 555, inhibit, Inhibitor, Papillomavirus, HER1, EGFR, Epidermal growth factor receptor, ErbB-1, Reverse Transcriptase, ReverseTranscriptase, Tyrphostin AG 555, Tyrphostin B46, Tyrphostin AG555, Tyrphostin AG-555

Compound Identifiers

PubChem CID

2058