AG 555

SKU: orb1223342

Description

AG555 is a potent epidermal growth factor receptor (EGFR) kinase inhibitor.

Key Properties

• CAS Number: 133550-34-2
• MW: 322.36
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₈N₂O₃
• SMILES: c1ccc(cc1)CCCNC(=O)/C(=C/c1cc(c(cc1)O)O)/C#N
• Target: BMI-1
• Solubility: DMSO : ≥ 100 mg/mL. 310.21 mM

Bioactivity

• In Vitro:
  AG 555 (100 μM) inhibits both the early stages (integration process) and the late stages (viral protein synthesis) in the virus life cycle. Tyrphostins AG555, which blocks Cdk2 activation, induces growth arrest of immortalized cells at G1-S and early S and is very effective in arresting the growth of EGFR overexpressor cells. Tyrphostin AG 555 can selectively suppress BPV-1 transcription through MAP kinase pathway activation and binding of phosphorylated Jun/ATF-2 at a novel intragenic regulatory sequence. Cell Proliferation Assay Cell line: NIH/3T3 uninfected cells and NIH/3T3-Mo-MuLV chronically infected cells. Concentration: 100 μM. Incubation time: 1 hour. Result: Inhibited Mo-MuLV proviral DNA integration.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AG555 | AG 555 | AG-555

Quick Database Links

Gene Symbol

BMI-1