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AG-494

SKU: orb1303064

Description

AG-494 (Tyrphostin B48) is a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It is widely used in biochemical research to study EGFR signaling pathways in both cellular and animal models of proliferation and oncology.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number133550-35-3
MW280.28
Purity99.50% (May vary between batches)
FormulaC16H12N2O3
SMILESOc1ccc(\C=C(/C#N)C(=O)Nc2ccccc2)cc1O
TargetEGFR,CDK
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.14 mM);Ethanol:1.4 mg/mL (5 mM);DMSO:14 mg/mL (49.95 mM)

Bioactivity

Target IC50
EGFR:0.7 μM (IC50)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CDK, activation, AG 494, AG494, AG-494, EGFR, osteogenic, Tyrphostin AG494, Tyrphostin AG-494, Tyrphostin B48, Tyrphostin AG 494

Similar Products

  • AG 494 [orb1223341]

    >98% (HPLC)

    133550-35-3

    280.3

    C16H12N2O3

    25 mg, 50 mg, 100 mg, 200 mg, 1 g, 500 mg, 5 mg, 10 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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AG-494 (orb1303064)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 70.00
25 mg
$ 100.00
50 mg
$ 130.00
100 mg
$ 190.00
200 mg
$ 250.00
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