AG 494

SKU: orb1223341

Description

AG-494, also known as Tyrphostin AG-494, is an inhibitor of epidermal growth factor receptor kinase with an IC50 value of 1 μM in HT-22 cells

Key Properties

• CAS Number: 133550-35-3
• MW: 280.28
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₂N₂O₃
• SMILES: c1ccc(cc1)NC(=O)/C(=C/c1cc(c(cc1)O)O)/C#N
• Target: TLR
• Solubility: In Vitro: DMSO : 100 mg/mL (356.79 mM)

Bioactivity

• In Vitro:
  In DHER-14 cells, AG 494 inhibits Cdk2 activation and EGF-dependent DNA synthesis. AG-494 significantly prevents NF-kB activation in silica-stimulated cells, and also reduces NF-kB activation in H2O2-treated cells. AG-494 (3-9 μM; 5-7 days) inhibits BMP9-induced ALP activity in a dose-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AG-494 | AG 494 | AG494 | Tyrphostin AG-494.

Quick Database Links

Gene Symbol

TLR