Aftin-4

• Catalog Number: orb1302916
• Category: Small Molecules
• Description: Aftin-4
• Purity: 99.03%
• MW: 368.48
• Biological Activity: Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4(Aftin4) can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.
• CAS Number: [866893-90-5]
• Formula: C₂₀H₂₈N₆O
• SMILES: CC[C@H](CO)Nc1nc(N(C)Cc2ccccc2)c2ncn(C(C)C)c2n1
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.