Aftin-4

• Catalog Number: orb1302916
• Category: Small Molecules
• Description: Aftin-4
• CAS Number: 866893-90-5
• Purity: 99.03%
• MW: 368.48
• SMILES: C(C)(C)N1C=2C(=C(N(CC3=CC=CC=C3)C)N=C(N[C@H](CC)CO)N2)N=C1
• Formula: C₂₀H₂₈N₆O
• Biological Activity: Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4(Aftin4) can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.