Aftin-4

SKU: orb1302916

Description

Aftin-4 is a γ-secretase activator that selectively increases Aβ1-42 production. This small molecule induces acute Alzheimer's disease-like pathology, including hippocampal learning deficits and mitochondrial alterations in rodent models, making it a valuable tool for in vivo and in vitro research on amyloid toxicity and AD mechanisms.

Research Area

Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 866893-90-5
• MW: 368.48
• Purity: 99.03% (May vary between batches)
• Formula: C₂₀H₂₈N₆O
• SMILES: CC[C@H](CO)Nc1nc(N(C)Cc2ccccc2)c2ncn(C(C)C)c2n1
• Target: Gamma-secretase,Beta Amyloid
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.43 mM);DMSO:55 mg/mL (149.26 mM)

Bioactivity

• Animal Research:
  Brains of 4-mo-old C57BL/6 wild-type mice were dissected and mechanically disassociated in HBSS with a tissue homogenizer. Aliquots from each mouse were incubated with DMSO and two concentrations of Aftin-4 at 37°C for 3 h. Liquefied brains were sonicated and centrifuged at 13,000 rpm for 15 min. WB analysis was performed using CT695 antibody for soluble Aβ-CTF. They are for reference only.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Abeta, Aftin 4, Aftin4, Aftin-4, b Amyloid, Amyloid-β, bAmyloid, BetaAmyloid, Beta Amyloid, Gammasecretase, Inhibitor, inhibit, γ secretase(Aβ42), β-amyloid peptide, βAmyloid, β Amyloid

Compound Identifiers

PubChem CID

5289296