AFN-1252

SKU: orb1303155

Description

AFN-1252 (Debio 1452) is a potent FabI enoyl-ACP reductase inhibitor active against clinical isolates of Staphylococcus aureus and S. epidermidis (MIC ≤0.12 µg/ml). It serves as a valuable research tool for studying bacterial fatty acid biosynthesis and has demonstrated efficacy in preclinical models of staphylococcal infection.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 620175-39-5
• MW: 375.42
• Purity: 99.81% (May vary between batches)
• Formula: C₂₂H₂₁N₃O₃
• SMILES: CN(Cc1oc2ccccc2c1C)C(=O)\C=C\C1=CNC2=NC(=O)CCC2=C1
• Target: Antibacterial,Antibiotic
• Solubility: DMSO:5.8 mg/mL (15.45 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AFN 1252, AFN1252, AFN-1252, API1252, API-1252, API 1252, Antibiotic, Bacterial, inhibit, Inhibitor, enoyl-acyl carrier protein reductase (FabI), Debio 1452, Debio1452, Debio-1452

Compound Identifiers

PubChem CID

10407120