AFN-1252

SKU: orb1224434

Description

A potent inhibitor of bacterial enoyl-ACP reductase FabI; demonstrates MICs of 0.015 and 0.008 ug/ml for S. aureus ATCC 29213 and S. aureus ATCC 33592 (MRSA), respectively; demonstrates a Staphylococcus-specific spectrum of activity.Bacterial Infection Phase 2 Clinical.

Key Properties

• CAS Number: 620175-39-5
• MW: 375.4204
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₁N₃O₃
• SMILES: O=C(N(C)CC1=C(C)C2=CC=CC=C2O1)/C=C/C3=CC(CC4)=C(N=C3)NC4=O
• Target: Antibacterial
• Solubility: DMSO: 5.8 mg/mL (Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: Female 5-to 6-week-old CD-1 mice (18 to 22 g) with S. aureus Smith bacterial inoculum. Dosage: 0.03, 0.1, 0.3, 1, 3 mg/kg. Administration: Oral gavage; single dose. Result: Was efficacious in a mouse model of septicemia, with 100% survival obtained with a single oral dose of 1 mg/kg. The calculated ED50s (95% confidence limits) were 0.15 (0.11 to 0.21) mg/kg.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

API-1252 | Debio-1452

Quick Database Links

Gene Symbol

Antibacterial