AEG 3482

SKU: orb1704944

Description

AEG 3482 is a cell-permeable small molecule that acts as a potent antiapoptotic agent by binding HSP90. This interaction promotes HSF1-mediated upregulation of HSP70, which subsequently inhibits JNK activity. It is utilized in research to study apoptosis, heat shock response, and neuroprotection in both cellular and animal models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 63735-71-7
• MW: 280.33
• Purity: >99.99% (May vary between batches)
• Formula: C₁₀H₈N₄O₂S₂
• SMILES: NS(=O)(=O)c1nn2cc(nc2s1)-c1ccccc1
• Target: Apoptosis,JNK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (17.84 mM);DMSO:200 mg/mL (713.44 mM)

Bioactivity

• In Vitro:
  AEG 3482 (0.3-30 μM; 2 d) inhibits nerve growth factor (NGF) withdrawal-induced death in SCG neurons, with an EC50 of ∼20 μM. AEG 3482 (10-40 μM; 30 h) inhibits p75NTR- and NRAGE-mediated JNK activation in PC12 cells. AEG 3482 (1-80 μM; 40 h) inhibits p75NTR- and NRAGE- mediated apoptosis of PC12 cells in a dose-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, AEG 3482, AEG3482, AEG-3482

Compound Identifiers

PubChem CID

698112