Adenosine 5-monophosphate disodium salt

SKU: orb2900674

Description

Adenosine 5'-monophosphate disodium is an orally active purine nucleotide, and participates in ATP metabolism. Adenosine 5'-monophosphate disodium is also a ligand for adenosine 2B receptor. Adenosine 5'-monophosphate disodium can activate AMPK in skeletal muscle, and ameliorates insulin resistance and impaired glucose metabolism. Adenosine 5'-monophosphate disodium can be used for research of diabetes.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 4578-31-8
• MW: 391.18
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₂N₅Na₂O₇P
• SMILES: [Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]1O
• Target: Antibiotic
• Solubility: In Vitro: H2O : 100 mg/mL (255.64 mM; Ultrasonic)

Bioactivity

• In Vivo:
  Animal model: C57BL/6 J mice with high-fat diet-induced diabetes. Dosage: 10 and 13 mg/L. Administration: Added in distilled water, for 25 weeks. Result: Enhanced phosphorylation of AMPK and mRNA levels of genes involved in lipid oxidation in the skeletal muscle.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Antibiotic