Adapalene

SKU: orb1309802

Description

Adapalene

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 106685-40-9
• MW: 412.52
• Purity: 99.88%
• Formula: C₂₈H₂₈O₃
• SMILES: COC1=CC=C(C=C1C12CC3CC(CC(C3)C1)C2)C1=CC2=CC=C(C=C2C=C1)C(O)=O
• Target: Retinoid Receptor,Apoptosis,Autophagy
• Solubility: 10% DMSO+90% Corn Oil:1 mg/mL (2.42 mM);DMSO:12.5 mg/mL (30.3 mM)

Bioactivity

• Target IC50:
  RARα:22 nM (AC50)|RARβ:2.3 nM (AC50)|RARγ:9.3 nM (AC50)
• In Vivo:
  In colorectal cancer cell lines CC-531, HT-29, and LOVO, as well as in human foreskin fibroblasts, Adapalene induces caspase-3 activity in tumor cells, inhibits DNA synthesis in a time- and dose-dependent manner, and triggers apoptosis.
• In Vitro:
  In rhino mice, Adapalene reduces the quantity of comedonal melanin in the epidermis and increases epidermal thickness. Within both normal skin and acne explants, Adapalene decreases the expression of TLR-2 (TLR-2) and IL-10 (IL-10). By upregulating CD1d expression and downregulating the IL-10 expression in keratinocytes, Adapalene modulates the epidermal immune system. This action enhances the interaction between dendritic cells and T lymphocytes, augmenting antimicrobial activity against Propionibacterium acnes.

Storage & Handling

• Storage: keep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, GOT1, Inhibitor, Adapalene, acne, Apoptosis, Autophagy, CD-271, CD271, CD 271, RetinoidReceptor, Retinoid Receptor, Retinoid X receptors, Retinoic acid receptors, retinoid, RXR, RAR, RAR/RXR, RARα, RARγ, RARβ, tumor

Compound Identifiers

PubChem CID

60164