Adapalene

SKU: orb1227043

Description

Adapalene is a topical retinoid primarily used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. It is currently marketed by Galderma under the trade names Differin in some countries, and Adaferin in India. \n(In Vitro):Adapalene (1-200 μM; 24 h) inhibits the viability of ES-2, HOV-7, MCF-7 , Hela, SW1990, HT1080, and MM-468 cells, with IC50s of 10.36 μM, 10.81 μM, 12.00 μM, 19.08 μM, 19.52 μM, 21.70 μM, and 31.47 μM, respectively.Adapalene (10-40 μM; 24 h) induces ES-2 cells apoptosis and inhibits proliferation in vitro.Adapalene (3-30 μM; 6-24 h) significantly increases the G1-phase population in LoVo or DLD1 cells.Adapalene (1-200 μM) inhibits GOT1 activity, with an IC50 of 21.79 μM.Adapalene (10-6-10-3 nM) inhibits the expression of plasma membrane-associated enzyme transglutaminase Type I, with an IC50 of 2.5 nM.(In Vivo):Adapalene (15-100 mg/kg; p.o. daily for 21 days) inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 106685-40-9
• MW: 412.52
• Purity: >98% (HPLC)
• Formula: C₂₈H₂₈O₃
• SMILES: COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5
• Target: Retinoid Receptor
• Solubility: DMSO: 8 mg/mL (19.39 mM)

Bioactivity

• In Vivo:
  Animal model: Female BALB/C nude mice (15 g, 4-5 weeks) were injected with DLD1 cells. Dosage: 15, 20, 65, 100 mg/kg. Administration: p.o. daily for 21 days. Result: Significantly reduced tumor weight and volume.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CD 271

Quick Database Links

Gene Symbol

Retinoid Receptor