AD57

SKU: orb1704705

Description

AD57 is a potent dual inhibitor of c-Src and Abl kinases, exhibiting IC50 values of 25 nM and 41 nM, respectively. This small molecule is a valuable research tool for studying oncogenic signaling in vitro and has been utilized in cellular models of cancer proliferation and metastasis.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1093380-42-7
• MW: 455.44
• Purity: 99.05% (May vary between batches)
• Formula: C₂₂H₂₀F₃N₇O
• SMILES: CC(C)n1nc(-c2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2)c2c(N)ncnc12
• Target: Bcr-Abl,Src,Raf,S6 Kinase,c-RET
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.39 mM);DMSO:55 mg/mL (120.76 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Abl, AD 57, AD57, AD-57, BcrAbl, c-Src

Compound Identifiers

PubChem CID

25011745