AD57 (hydrochloride)

SKU: orb1704706

Description

AD57 is a polypharmacological small molecule that potently inhibits the RET tyrosine kinase (IC50: 2 nM) and disrupts downstream effectors like Raf and Src. This multi-target action suppresses oncogenic signaling pathways, making it a useful research tool for studying RET-driven cancers such as medullary thyroid carcinoma in both cellular and animal models.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2320261-72-9
• MW: 491.9
• Formula: C₂₂H₂₁ClF₃N₇O
• SMILES: Cl.CC(C)n1nc(-c2ccc(NC(=O)Nc3cccc(c3)C(F)(F)F)cc2)c2c(N)ncnc12
• Target: Src,S6 Kinase,c-RET,Raf,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

132285143