ACP-105

SKU: orb1940737

Description

ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.(In Vitro):ACP-105 is an SARM with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively. The half-lives of ACP-105 in human hepatocytes is 5.0 h.(In Vivo):Irradiation impaired sensorimotor function in vehicle-treated mice but not in ACP-105-treated mice. Irradiation impaired cued fear conditioning and ACP-105 enhanced fear conditioning in sham-irradiated and irradiated mice. There are relatively early radiation-induced behavioral changes in female mice and reduced MAP-2 levels in the sensorimotor cortex following ACP-105 treatment might contribute to enhanced rotorod performance.

Key Properties

• CAS Number: 899821-23-9
• MW: 290.79
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₉ClN₂O
• SMILES: Cc1c(Cl)c(ccc1N1[C@H]2CC[C@@H]1C[C@](C)(O)C2)C#N
• Target: Androgen Receptor (AR)
• Solubility: In Vitro: DMSO : ≥ 103 mg/mL (354.21 mM)

Bioactivity

• In Vivo:
  ACP-105 enhances freezing in both sham-irradiated and irradiated mice (effect of ACP-105: F = 5.44; p = 0.028). For MAP-2 immunoreactivity in the cortex of sham-irradiated mice, there is a brain area×ACP-105 interaction (F = 6.655; p = 0.0027). While ACP-105 reduces MAP-2 immunoreactivity in the sensorymotor cortex, there is a trend towards increased MAP-2 immunoreactivity in the enthorhinal cortex.
• In Vitro:
  ACP-105 is an orally available, selective amd potent androgen receptor modulator (SARM), with pEC50s of 9.0 and 9.3 for AR wild type and T877A mutant, respectively. The half-lives of ACP-105 (compound 1) in human hepatocytes is measured and found to be 5.0 h.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Androgen Receptor (AR)