ACP-105

SKU: orb1308694

Description

ACP-105

Research Area

Metabolism Research

Key Properties

• CAS Number: 899821-23-9
• MW: 290.79
• Purity: 99.53%
• Formula: C₁₆H₁₉ClN₂O
• SMILES: Cc1c(Cl)c(ccc1N1[C@H]2CC[C@@H]1C[C@](C)(O)C2)C#N
• Target: Androgen Receptor
• Solubility: Ethanol:60 mg/mL (206.33 mM);DMSO:60 mg/mL (206.33 mM)

Bioactivity

• Target IC50:
  AR (T877A):9.3 (pEC50)|AR (WT):9.0 (pEC50)
• In Vivo:
  Irradiation impaired sensorimotor function in vehicle-treated mice but not in ACP-105-treated mice. Irradiation impaired cued fear conditioning and ACP-105 enhanced fear conditioning in sham-irradiated and irradiated mice. There are relatively early radiation-induced behavioral changes in female mice and reduced MAP-2 levels in the sensorimotor cortex following ACP-105 treatment might contribute to enhanced rotorod performance.
• In Vitro:
  ACP-105 is an orally administered, selective, and potent androgen receptor modulator (SARM), demonstrating high affinity with pEC50 values of 9.0 and 9.3 for the AR wild type and T877A mutant, respectively. In human hepatocytes, the half-life of ACP-105 (compound 1) is determined to be 5.0 hours.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Androgen Receptor, AndrogenReceptor, AR T877A mutant, AR wild type, ACP105, ACP-105, ACP 105, inhibit, Inhibitor

Compound Identifiers

PubChem CID

11638442