ACH-000143

SKU: orb1298295

Description

ACH-000143 is a novel small molecule agonist that selectively targets and activates melatonin receptors MT1 and MT2. It is a valuable research tool for investigating circadian rhythms, sleep disorders, and neuroprotection in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2225836-30-4
• MW: 297.74
• Purity: 98.15% (May vary between batches)
• Formula: C₁₃H₁₆ClN₃O₃
• SMILES: COc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O
• Target: MT Receptor,Melatonin Receptor
• Solubility: DMSO:60 mg/mL (201.52 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.72 mM)

Bioactivity

• Target IC50:
  MT1:0.06 nM(EC50)|MT2:0.32 nM(EC50)
• In Vivo:
  Two-month oral administration of ACH-000143 in high-fat diet rats led to a reduction in body weight gain similar to dapagliflozin with superior results on hepatic steatosis and triglyceride levels.
• In Vitro:
  ACH-000143 demonstrated subnanomolar potency at MT1/MT2 receptors, high oral bioavailability in rodents, peripherally preferred exposure, and excellent selectivity in a broad panel of targets.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ACH 000143, ACH000143, ACH-000143, Inhibitor, HFD, Melatonin Receptor, MelatoninReceptor, inhibit, MTReceptor, MT1 receptor, MT2 receptor, MT Receptor, low, obese, toxicity, steatosis

Compound Identifiers

PubChem CID

139451790