ACH-000143

SKU: orb1218410

Description

ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.

Key Properties

• CAS Number: 2225836-30-4
• MW: 297.74
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₆ClN₃O₃
• SMILES: CC(NCCN1C2=CC(OC)=C(Cl)C=C2N=C1OC)=O
• Target: MT1 receptor|MT2 receptor
• Solubility: In Vitro: DMSO : 50 mg/mL (167.93 mM)

Bioactivity

• In Vivo:
  ACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats. ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o. , supporting further investigation of this compound as a drug candidate. ACH-000143 significantly reduces plasma glucose at 10 mg/kg (16.4%, p < 0.05) and 30 mg/kg (16.9%, p < 0.01). Animal model: High-fat diet rats. Dosage: 10 and 30 mg/kg. Administration: Orally, once daily for two months. Result: Significantly reduced the weekly BW gain on weeks.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

MT1 receptor|MT2 receptor