Acetoacetic acid sodium salt

SKU: orb1308873

Description

Acetoacetic acid sodium salt is a ketone body metabolite derived from fatty acid catabolism. It serves as a critical research tool for studying metabolic disorders, particularly in diabetes research models, to investigate ketosis and metabolic dysregulation in both in vitro and in vivo experimental systems.

Research Area

Metabolism Research

Key Properties

• CAS Number: 623-58-5
• MW: 124.07
• Purity: ≥98% (May vary between batches)
• Formula: C₄H₅NaO₃
• SMILES: CC(=O)CC(=O)[O-].[Na+]
• Target: Endogenous Metabolite,Others
• Solubility: H2O:101 mg/mL (814.06 mM)

Bioactivity

• In Vitro:
  Acetoacetic acid sodium salt triggers oxidative stress, thereby impeding very-low-density lipoprotein (VLDL) assembly in bovine hepatocytes. This compound, at concentrations of 0.6, 2.4, and 4.8 mM, increases malondialdehyde (MDA) content in the high-dose group (GH), diminishes mRNA levels of Mn-SOD, Cu/Zn SOD, and glutathione peroxidase (GSH-Px) across all groups, and reduces catalase (CAT) mRNA expression in the medial-dose (GM) and GH groups. Furthermore, it suppresses mRNA expression of apolipoprotein B100 (ApoB100), apolipoprotein E (ApoE), and the low-density lipoprotein receptor (LDLR), leading to reduced VLDL assembly and heightened triglyceride (TG) accumulation in bovine hepatocytes.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Acetoacetic acid, Acetoacetic acid sodium, Acetoacetic acid sodium salt, Endogenous Metabolite

Compound Identifiers

PubChem CID

23678750