Acetoacetic acid sodium salt

SKU: orb1217804

Description

Acetoacetic acid sodium salt is a metabolite of non-esterified fatty acids, involved in the development of human diabetes.

Images & Validation

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Key Properties

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CAS Number	623-58-5
MW	124.07
Purity	>98% (HPLC)
Formula	C₄H₅NaO₃
SMILES	CC(=O)CC(=O)[O-].[Na+]
Target	Others
Solubility	H2O:50 mg/mL (403.00 mM; Need ultrasonic)

Bioactivity

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In Vitro

Acetoacetic acid sodium induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes. Acetoacetic acid (0.6, 2.4, 4.8 mM) increases malondialdehyde (MDA) content in high-dose group (GH) group, decreases mRNA expression of Mn SOD, Cu/Zn SOD, and glutathione peroxidase (GSH-Px) in all groups, lowers catalase (CAT) mRNA expression in medial-dose group (GM), and GH groups. In addition, Acetoacetic acid down-regulates the mRNA expression of apolipoprotein B100 (ApoB100), apolipoprotein E (ApoE), and low density lipoprotein receptor (LDLR). Thus, VLDL assembly is decreased andtriglyceride (TG) accumulation is increased in these bovine hepatocytes.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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