ABP/PPAR modulator 1

SKU: orb3027440

Description

ABP/PPAR modulator 1 is an orally active multi-regulator of FABP and PPAR, exhibiting IC50 values of 0.65 μM for FABP1 and 1.08 μM for FABP4, and EC50 values of 9.19 μM, 2.20 μM, and 1.58 μM for PPARα, PPARγ, and PPARδ, respectively. It demonstrates potent activity against metabolic dysfunction-associated steatohepatitis (MASH). Additionally, ABP/PPAR modulator 1 dose-dependently improves various pathological features of fatty liver in a WD + Carbon tetrachloride-induced MASH mouse model.

Research Area

Metabolism Research, Molecular Biology

Key Properties

• MW: 561.67
• Formula: C₃₃H₃₉NO₇
• SMILES: COC1=CC=C(/C=C/C2=CC(OC)=CC(OCC3=CC=C(OC(C(N[C@@H](C(O)=O)CC(C)C)=O)(C)C)C=C3)=C2)C=C1
• Target: PPAR,FABP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PPAR,FABP