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(E/Z)-ABP/PPAR modulator 1

SKU: orb3173493

Description

ABP/PPAR modulator 1 is an orally active modulator targeting FABP and PPAR, with IC50 values of 0.65 μM and 1.08 μM for FABP1 and FABP4, respectively, and EC50 values of 9.19 μM, 2.20 μM, and 1.58 μM for PPARα, PPARγ, and PPARδ, respectively. It demonstrates potent anti-metabolic dysfunction-associated steatohepatitis (MASH) activity. ABP/PPAR modulator 1 dose-dependently improves various pathological features of fatty liver in a WD + Carbon tetrachloride-induced MASH mouse model.

Images & Validation

Key Properties

TargetPPAR,FABP

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information