ABL1 (M) Antibody, Rabbit Polyclonal

SKU: orb66952

Description

Rabbit polyclonal to ABL1.The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has beenimplicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activityof ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turnsABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR(MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNAbindingactivity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediatedphosphorylation, suggesting a cell cycle function for ABL1 (provided by RefSeq).

Images & Validation

• Tested Applications: WB
• Dilution range: WB:1:1000-1:5000
• Reactivity: Human

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: middle region of human ABL1
• Molecular Weight: 123
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Disclaimer: For research use only

Alternative Names

anti-ABL1 antibody,anti-cabl oncogene 1 antibody,anti-nonreceptor tyrosine kinase antibody,anti-ABL; JTK7; p150; cABL; vabl; bcr antibody,anti-abl antibody,anti-Abelson murine leukemia viral oncogene homolog 1 antibody

Western blot of total cell extracts from human K562, using Ab (orb66952) at RT for 2 h.

Quick Database Links

UniProt

P00519