Abamectin

SKU: orb1224160

Description

Avermectin B1 (Abamectin) is a widely used insecticide and anthelmintic.

Key Properties

• CAS Number: 71751-41-2
• MW: 873.09
• Purity: >98% (HPLC)
• Formula: C₄₈H₇₂O₁₄
• SMILES: C[C@H]1[C@H](O)[C@@H](OC)C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]([C@@H](C)/C=C/C=C3CO[C@@]4([H])[C@]\3(O)[C@@]5([H])C=C(C)[C@H]4O)/C(C)=C/C[C@]6([H])C[C@H](OC5=O)C[C@@]7(O[C@H](C(C)C)[C@@H](C)C=C7)O6)C[C@@H]2OC)O1.C[C@H]8[C@H](O)[C@@H](OC)C[C@H](O[C@H]9[C@H](C)O[C@@H](O[C@@H]([C@@H](C)/C=C/C=C%10CO[C@@]%11([H])[C@]\%10(O)[C@@]%12([H])C=C(C)[C@H]%11O)/C(C)=C/C[C@]%13([H])C[C@H](OC%12=O)C[C@@]%14(O[C@H]([C@@H](CC)C)[C@@H](C)C=C%14)O%13)C[C@@H]9OC)O8
• Target: Antiparasitic
• Solubility: DMSO: 10 mM

Bioactivity

• In Vivo:
  Animal model: Horses (had a pruritic dermatosis). Dosage: 0.2 mg/kg, a single dose. Administration: Oral administration. Result: Decreased in mean strongyle egg counts 14, 28 and 42 d after treatment, and resulted in zero microfilaria counts in all horses 14 d after treatment. Animal model: Healthy adult female sheep (Pharmacokinetic assay). Dosage: 0.2 mg/kg. Administration: Subcutaneous administration (in the left neck area of each sheep). Result: Pharmacokinetic profiles of Avermectin B1.
• In Vitro:
  Cell Viability Assay Cell line: Mouse embryonic fibroblast (MEF) cells. Concentration: 0, 0.5, 5, 10, 20, 40, 80 μM Incubation time: 12 h. Result: Reduced cell viability with an IC50 value of 45.6 μM. Western blot analysis. Cell line: MGC803 cells. Concentration: 0-4 μM. Incubation time: 24 h. Result: Increased active caspase-3 and expression of Bax/Bcl-2, decreased MMP in a dose-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Abamectin, Affirm, Avid, Avid EC, Avomec, EPA Pesticide Chemical Code 122804, HSDB 6941, MK 0936

Quick Database Links

Gene Symbol

Antiparasitic