AA26-9

SKU: orb1303468

Description

AA26-9 is a potent, broad-spectrum serine hydrolase inhibitor. It is a valuable research tool for studying lipid signaling and metabolic pathways in both in vitro enzymatic assays and in vivo model systems.

Research Area

Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 1312782-34-5
• MW: 166.18
• Purity: 99.88% (May vary between batches)
• Formula: C₇H₁₀N₄O
• SMILES: O=C(N1CCCC1)n1ccnn1
• Target: Phospholipase,Serine Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (12.04 mM);DMSO:55 mg/mL (330.97 mM)

Bioactivity

• In Vitro:
  AA26-9 inhibits enzymes originated from diverse functional subclasses of serine hydrolases, including peptidases (APEH, CTSA, PRCP), thioesterases (LYPLA1/2), lipases/phospholipases (AADACL1, ESD, ABHD6, PAFAH2, FAAH, LYPLA3), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells.
• Cell Research:
  AA26-9 is prepared in DMSO. Cells are cultured with 20 μM inhibitor AA26-9 or DMSO as a control for 4 h, lysed, separated into soluble and analyzed by competitive gel-based ABPP.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

peptidases, SerineProtease, serine, serine hydrolase, thioesterases, Serine Protease, Phospholipase, inhibit, lipases, Inhibitor, esterases, AA26 9, AA269, AA-26-9, AA26-9, amidases, cell

Compound Identifiers

PubChem CID

46829239