AA26-9

SKU: orb1223347

Description

AA26-9 is a potent and broad-spectrum serine hydrolase inhibitor. AA26-9-inhibited enzymes originated from diverse functional subclasses of serine hydrolases, including lipases/phospholipases, thioesterases, and uncharacterized enzymes.

Key Properties

• CAS Number: 1312782-34-5
• MW: 166.18
• Purity: >98% (HPLC)
• Formula: C₇H₁₁N₄O
• SMILES: O=C(N1CCCC1)N2N=NC=C2
• Target: FAAH
• Solubility: DMSO : 100 mg/mL. 601.76 mM

Bioactivity

• In Vitro:
  AA26-9 is synthesized based on a piperazine scaffold shown previously to inhibit serine hydrolases in the context of p-nitrophenoxy carbamate. AA26-9-inhibited enzymes originated from diverse functional subclasses of serine hydrolases, including lipases/phospholipases (AADACL1, ABHD6, ESD, FAAH, PAFAH2, LYPLA3), peptidases (APEH, PRCP, CTSA), thioesterases (LYPLA1, LYPLA2), and uncharacterized enzymes (ABHD11, ABHD13, BAT5). AA26-9 inhibits one of its enzyme targets LYPLA1 by covalent carbamoylation of the enzyme’s serine nucleophile (S114). AA26-9 inhibits 1/3 of the over 40 serine hydrolase found in T-cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AA 26-9 | AA-26-9 | AA26-9 | AA 269

Quick Database Links

Gene Symbol

FAAH