A2A receptor antagonist 1

SKU: orb1303759

Description

This compound is a dual adenosine receptor antagonist, exhibiting high affinity for the A2A receptor (Ki = 4 nM) and moderate affinity for the A1 receptor (Ki = 264 nM). As a CPI-444 analog, it is a valuable research tool for investigating adenosine signaling in oncology and immunology, supporting both in vitro binding assays and in vivo tumor model studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 443103-97-7
• MW: 309.3
• Purity: 99.93% (May vary between batches)
• Formula: C₁₆H₁₂FN₅O
• SMILES: Nc1nc(-c2ccco2)c2cnn(Cc3ccccc3F)c2n1
• Target: Adenosine Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.47 mM);DMSO:50 mg/mL (161.66 mM)

Bioactivity

• Target IC50:
  A1 receptor:264 nM (Ki)|A2A receptor:4 nM (Ki)
• In Vitro:
  A2A receptor anyagonist 1 is a potent adenosine A2A receptor antagonist, selective over the A1 receptor and demonstrate its binding activity with Ki values of 4 and 264 nM, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A2A receptor antagonist 1, A2A/A1, AdenosineReceptor, Adenosine Receptor, CPI 444, CPI444, CPI-444, CPI-444 analog, disease, model, Parkinson, inhibit, Inhibitor, hypolocomotion, P1 receptor

Compound Identifiers

PubChem CID

9879687