A-836339

SKU: orb1299873

Description

A-836339 is a potent full agonist of cannabinoid receptors, exhibiting a strong selectivity for the peripheral CB2 receptor over the central CB1 receptor. It demonstrates analgesic, anti-inflammatory, and anti-hyperalgesic properties in murine models, making it a valuable research tool for studying pain, inflammation, and neuroimmunology.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 959746-77-1
• MW: 310.45
• Purity: 99.94% (May vary between batches)
• Formula: C₁₆H₂₆N₂O₂S
• SMILES: COCCn1c(C)c(C)s\c1=N/C(=O)C1C(C)(C)C1(C)C
• Target: Cannabinoid Receptor
• Solubility: DMSO:12 mg/mL (38.65 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.61 mM)

Bioactivity

• In Vivo:
  A-836339 was characterized extensively in various animal pain models. In the complete Freund's adjuvant model of inflammatory pain, A-836339 exhibits a potent CB(2) receptor-mediated antihyperalgesic effect that is independent of CB(1) or mu-opioid receptors. A-836339 has also demonstrated efficacies in the chronic constrain injury (CCI) model of neuropathic pain, skin incision, and capsaicin-induced secondary mechanical hyperalgesia models. Furthermore, no tolerance was developed in the CCI model after subchronic treatment with A-836339 for 5 days.
• Animal Research:
  The plantar aspect of the rat left hind paw was exposed through a hole in a sterile plastic drape, and a 1-cm longitudinal incision was made through the skin and fascia, starting 0.5 cm from the proximal edge of the heel and extending toward the toes. The plantaris muscle was elevated and incised longitudinally, leaving the muscle origin and insertion points intact. After homeostasis by application of gentle pressure, the skin was apposed with two mattress sutures using 5-0 nylon. Animals were then allowed to recover for 2 or 24 h after surgery, at which time mechanical allodynia was assessed.To test drug effects, rats were first acclimated for 20 min in inverted individual plastic containers (20*12.5*20 cm) on top of a suspended wire mesh grid, and A-836339 was injected intraperitoneally 30 min before testing for mechanical allodynia using calibrated von Frey filaments . von Frey filaments were presented perpendicularly to the plantar surface of the selected hind paw and then held in this position for approximately 8 s, with enough force to cause a slight bend of the filament. Positive responses included an abrupt withdrawal of the hind paw from the stimulus or flinching behavior immediately after removal of the stimulus. A 50% withdrawal threshold was determined using an up-down procedure.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CB, A836339, A-836339, A 836339, CannabinoidReceptor, Cannabinoid Receptor, inhibit, Inhibitor

Compound Identifiers

PubChem CID

17754357