A-804598

SKU: orb1303970

Description

A-804598

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1125758-85-1
• MW: 315.37
• Purity: 99.80%
• Formula: C₁₉H₁₇N₅
• SMILES: C[C@H](N(C(=N)NC#N)c1cccc2ncccc12)c1ccccc1
• Target: P2X Receptor
• Solubility: DMSO:31.5 mg/mL (99.88 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.34 mM)

Bioactivity

• Target IC50:
  P2X7 receptor (rat):10 nM|P2X7 receptor (rat):9 nM|P2X7 receptor (human):11 nM
• In Vivo:
  According to the autoradiographic analysis of coronal rat brain sections, there was specific binding of [3H]-A-804598 throughou the rat brain. in the grey matter o the L4-L6 region o the rat spinal cord, it was also found that high levels of [3H]-A-804598 specific binding.
• In Vitro:
  A-804598 effectively blocked IL-1β release in the THP-1 cells IC50 8.5 nM). It also blocked agonist-evoked pore formation in differentiated human THP-1 cells IC50 8.1 nM) with similar potency as in the calcium-influx assay.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, A 804598, A804598, A-804598, P2XReceptor, P2XRs, P2X7, P2X Receptor

Compound Identifiers

PubChem CID

91895232