A-804598

SKU: orb1223426

Description

A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human).

Key Properties

• CAS Number: 1125758-85-1
• MW: 315.37
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₇N₅
• SMILES: C[C@@H](c1ccccc1)N=C(NC#N)Nc1cccc2c1cccn2
• Target: MAO
• Solubility: DMSO : ≥ 32 mg/mL 101.47 mM

Bioactivity

• In Vivo:
  A chroni treatment with A-804598 (intraperitoneal injection; 30 mg/kg; five times a week) decreases the expression of LC3B-II and SQSTM1/p62 in lumbar spinal cord at end stage of disease. Animal model: Adult B6.Cg-Tg (SOD1-G93A) 1Gur/J female mice. Dosage: 30 mg/kg. Administration: Intraperitoneal injection; five times a week. Result: Decreased SQSTM1/p62 expression.
• In Vitro:
  Pre-incubation with A-804598 (0.1-10 μM; 1 hour) significantly attenuates BzATP-induced cell loss in a concentration-dependent manner. 3 μM A-804598 exhibits the greatest protective effect against BzATP-induced cytotoxicity. Cell Cytotoxicity Assay Cell line: microglial cell. Concentration: 0.1, 0.3, 1, 3, 10 μM Incubation time: 1 hour. Result: Protected against BzATP-induced cytotoxicity in both inactivated and activated microglia.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A-804598 | A 804598 | A804598.

Quick Database Links

Gene Symbol

MAO