A-740003

SKU: orb1223831

Description

A-740003 (A740003) is a potent, selective, competitive P2X7 receptor antagonist with IC50 of 40 nM and 18 nM for hP2X7 and rP2X7, respectively; showed weak or no activity for other P2 receptors (IC50>10 uM); potently blocks agonist-evoked IL-1β release (IC50=156 nM) and pore formation (IC50=92 nM) in differentiated human THP-1 cells; produces dose-dependent antinociception in a spinal nerve ligation model (ED50=19 mg/kg i.p.) in the rat.Pain Discontinued.

Key Properties

• CAS Number: 861393-28-4
• MW: 474.5548
• Purity: >98% (HPLC)
• Formula: C₂₆H₃₀N₆O₃
• SMILES: O=C(NC(/N=C(NC#N)\NC1=C2C=CC=NC2=CC=C1)C(C)(C)C)CC3=CC=C(OC)C(OC)=C3
• Target: P2X Receptor
• Solubility: 10 mM in DMSO

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A 740003 | A740003

Quick Database Links

Gene Symbol

P2X Receptor