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A-582941

SKU: orb3210813

Description

A-582941 is a selective α7nAChR agonist that is orally active and capable of crossing the blood-brain barrier. It exhibits Ki values of 10.8 nM in rat brains and 17 nM in the human frontal cortex. The compound also acts as an agonist at 5-HT3 receptors with a Ki of 150 nM. A-582941 is known to induce phosphorylation of ERK1/2 and CREB, inhibit GSK-3β via Ser-9 phosphorylation, increase acetylcholine release, and stimulate the expression of Arc and c-Fos. This activation occurs in brain regions associated with working memory and attention, and A-582941 reduces cell death caused by nerve growth factor (NGF) deprivation. It is applicable in research on Alzheimer's disease and schizophrenia.

Images & Validation

Key Properties

CAS Number848591-89-9
MW280.37
FormulaC17H20N4
SMILESN=1N=C(C=CC1C=2C=CC=CC2)N3CC4CN(C)CC4C3
TargetEpigenetic Reader Domain,AChR,ERK,5-HT Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information