A 582941 HCl (848591-90-2(free base))

SKU: orb1298683

Description

A-582941 is a potent and selective agonist of the α7 nicotinic acetylcholine receptor. It is utilized in neuroscience research to investigate cognitive function, with applications in both in vitro binding assays and in vivo models of learning and memory deficits.

Research Area

Neuroscience

Key Properties

• MW: 316.83
• Purity: 98.76% (May vary between batches)
• Formula: C₁₇H₂₁ClN₄
• SMILES: Cl.CN1C[C@H]2CN(C[C@H]2C1)c3ccc(nn3)c4ccccc4
• Target: AChR
• Solubility: DMSO:12 mg/mL (37.88 mM)

Bioactivity

• In Vitro:
  A-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs, with acceptable pharmacokinetic properties and excellent distribution to the central nervous system (CNS). In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation. A-582941 enhanced cognitive performance in behavioral models that capture domains of working memory, short-term recognition memory, memory consolidation, and sensory gating deficit. A-582941 exhibited a benign secondary pharmacodynamic and tolerability profile as assessed in a battery of assays of cardiovascular, gastrointestinal, and CNS function.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

α7 nAChR, A 582941 HCl (848591 90 2(free base)), A 582941 HCl (848591902(free base)), A 582941 HCl (848591-90-2(free base))

Compound Identifiers

PubChem CID

155977516