A 425619

SKU: orb1298831

Description

This small molecule is a potent and selective antagonist of the TRPV1 (vanilloid) receptor. It is a valuable research tool for studying pain, neurogenic inflammation, and thermal sensation in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 581809-67-8
• MW: 345.32
• Purity: 99.75% (May vary between batches)
• Formula: C₁₈H₁₄F₃N₃O
• SMILES: N(C(NCC1=CC=C(C(F)(F)F)C=C1)=O)C=2C3=C(C=CC2)C=NC=C3
• Target: Calcium Channel,TRP/TRPV Channel
• Solubility: DMSO:34.5 mg/mL (99.91 mM)

Bioactivity

• Target IC50:
  TRPV1:3-9 nM
• In Vivo:
  systemic administration of the TRPV1 antagonist, A-425619, reversed the decrease in digging behavior induced by CFA injection, further confirming the role of TRPV1, expressed by knee neurons, in acute inflammatory joint pain.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

A425619, A-425619, A 425619, 1-(4-(TRIFLUOROMETHYL)BENZYL)-3-(ISOQUINOLIN-5-YL)UREA, TRP Channel, TRPV Channel, TRPChannel, TRPV1, TRPVChannel

Compound Identifiers

PubChem CID

8068410