9-ING-41

SKU: orb1308709

Description

9-ING-41 is a potent and selective small molecule inhibitor of glycogen synthase kinase-3 (GSK-3). It is widely used in preclinical cancer research, demonstrating antitumor activity in both in vitro cell culture models and in vivo animal studies across various malignancies.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1034895-42-5
• MW: 404.35
• Purity: 99.32% (May vary between batches)
• Formula: C₂₂H₁₃FN₂O₅
• SMILES: Cn1cc(C2=C(C(=O)NC2=O)c2coc3ccc(F)cc23)c2cc3OCOc3cc12
• Target: GSK-3,Apoptosis,Autophagy
• Solubility: DMSO:97 mg/mL (239.89 mM)

Bioactivity

• Target IC50:
  GSK-3β:0.71 μM (IC50)
• In Vivo:
  In a mouse model of MCL, 9-ING-41 (40 mg/kg/every other day; for 17 days) has single-agent antitumor activity .
• In Vitro:
  9-ING-41 (2, 4 μM; 48 hours) decreases neuroblastoma cell viability induces apoptosis. 9-ING-41 (1, 2 μM; 24 hours) is a potent cell cycle-blocking agent for lymphoma cells. 9-ING-41 (0.1-1 μM) inhibits GSK-3 leading to a decreased expression of the NF-κB target XIAP and significant apoptosis in neuroblastoma cells as shown by PARP cleavage, an apoptosis marker. 9-ING-41 (0.5, 1.0, 1.5, 2.0 μM) inhibits the proliferation rate of all TCL and MCL lines with concentrations as low as 1.0 mM.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Glycogen synthase kinase-3, Glycogen synthase kinase 3, GSK3, GSK-3, GSK-3β, cycle, cell, anticancer, Apoptosis, Autophagy, arrest, activity, 9 ING 41, 9ING41, 9-ING-41

Compound Identifiers

PubChem CID

44582816