9-ING-41

SKU: orb1219637

Description

9-ING-41 is a glycogen synthase kinase-3 inhibitor.9-ING-41 (2, 4 μM; 48 hours) decreases neuroblastoma cell viability induces apoptosis. 9-ING-41 (0.1-1 μM) inhibits GSK-3 leading to a decreased expression of the NF-κB target XIAP and significant apoptosis in neuroblastoma cells as shown by PARP cleavage, an apoptosis marker. 9-ING-41 (0.5, 1.0, 1.5, 2.0 μM) inhibits the proliferation rate of all TCL and MCL lines with concentrations as low as 1.0 mM. 9-ING-41 (1, 2 μM; 24 hours) is a potent cell cycle-blocking agent for lymphoma cells[2].9-ING-41 (40 mg/kg/every other day; for 17 days) has single-agent antitumor activity in a mouse model of MCL.

Key Properties

• CAS Number: 1034895-42-5
• MW: 404.35
• Purity: >98% (HPLC)
• Formula: C₂₂H₁₃FN₂O₅
• SMILES: Cn1cc(C2=C(C(=O)NC2=O)c2coc3ccc(F)cc23)c2cc3OCOc3cc12
• Target: GSK-3
• Solubility: DMSO:97 mg/mL (239.89mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: NSG (NOD. Cg-PrkdcscidIl2rgtm1Wjl/SzJ) mice. Dosage: 40 mg/kg. Administration: Every other day; for 17 days. Result: Had single-agent antitumor activity in a mouse model of MCL.
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• In Vitro:
  Cell Viability Assay Cell line: TCL and MCL lines. Concentration: 2, 4 μM. Incubation time: 48 hours. Result: Induced apoptosis. Cell Cycle Analysis Cell line: Lymphoma cells (Jeko, Mino, and OCI-Ly cell lines). Concentration: 1, 2 μM. Incubation time: 24 hours. Result: Led to cell cycle arrest in G2/M. Cell Autophagy Assay Cell line: T24 cancer cells. Concentration: 25 μM. Incubation time: 24 hours. Result: Showed extensive vacuolation and formation of autophagosome like structures in the cytoplasm. Showed an increased expression of LC3, an autophagy marker. Western blot analysis. Cell line: SK-N-DZ and SK-N-BE neuroblastoma cells. Concentration: 0.1, 1 μM Incubation time: 48 hours. Result: Inhibited GSK-3 leading to a decreased expression of the NF-κB target XIAP.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

GSK-3