8-​Prenylnaringenin

SKU: orb1297527

Description

8-Prenylnaringenin is a potent phytoestrogen used in research to study estrogen receptor signaling. It is applied in both in vitro assays and in vivo models to investigate endocrine function, bone metabolism, and menopausal health.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 53846-50-7
• MW: 340.37
• Purity: 99.67%
• Formula: C₂₀H₂₀O₅
• SMILES: CC(C)=CCc1c(O)cc(O)c2C(=O)C[C@H](Oc12)c1ccc(O)cc1
• Target: Apoptosis,Sirtuin,ROS,PI3K,Akt,AMPK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.88 mM);DMSO:22.5 mg/mL (66.1 mM)

Bioactivity

• In Vitro:
  In vitro, aggregates of buccal epithelial cells were irradiated and cultured in suspension for 11 days. 8-PN or TAM were investigated regarding their effect on cell shedding. In vivo, the lower tongue surface of mice was irradiated with graded single doses of 25 kV X-rays. The incidence, latency, and duration of the resulting mucosal ulcerations were analyzed after topical treatment with 8-PN, TAM or solvent. 8-PN or TAM prevented the volume reduction of the irradiated cell aggregates during the incubation period. This was the result of a higher residual cell number in the treated versus the untreated irradiated aggregates. In vivo, topical treatment with 8-PN or TAM significantly increased the latency of mucositis from 10.9 to 12.1 and 12.4 days respectively, while the ulcer incidence was unchanged

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, 8-Prenylnaringenin, 8​Prenylnaringenin, 8-?Prenylnaringenin, 8 ​Prenylnaringenin, Estrogen Receptor/ERR, Inhibitor, inhibit, NF-κB, ROS

Compound Identifiers

PubChem CID

480764