(2S)-6-Prenylnaringenin

SKU: orb1297480

Description

(2S)-6-Prenylnaringenin is a stereoisomer of the potent phytoestrogen 8-prenylnaringenin. It functions as a highly effective positive allosteric modulator of the GABAA receptor at the α+β-interface, with notable activity in the forebrain, making it a valuable tool for neuropharmacology research in vitro and in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 68236-13-5
• MW: 340.37
• Purity: 99.47% (May vary between batches)
• Formula: C₂₀H₂₀O₅
• SMILES: CC(C)=CCc1c(O)cc2O[C@@H](CC(=O)c2c1O)c1ccc(O)cc1
• Target: GABA Receptor
• Solubility: DMSO:95.3 mg/mL (279.99 mM)

Bioactivity

• Target IC50:
  GABAA:3.7 μM
• In Vitro:
  In native GABAA receptors, 6-Prenylnaringenin potentiates GABA-induced displacement of [3H]EBOB binding in a concentration-dependent manner with IC50s of 3.7 μM. 6-Prenylnaringenin displays a modulatory activity at low micromolar concentrations.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(2S)6Prenylnaringenin, (2S) 6 Prenylnaringenin, 6-PN, 6-Prenylnaringenin, Inhibitor, inhibit, GABA Receptor, GABAA, GABAReceptor, Gamma-aminobutyric acid Receptor, Tyrosinase, γ-Aminobutyric acid Receptor

Compound Identifiers

PubChem CID

155094