8-M-PDOT

SKU: orb2901841

Description

8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity.

Key Properties

• CAS Number: 134865-70-6
• MW: 233.31
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₉NO₂
• SMILES: CCC(=O)NC1CCc2cccc(OC)c2C1
• Solubility: In Vitro: DMSO : 100 mg/mL (428.61 mM; Ultrasonic )

Bioactivity

• In Vivo:
  8-M-PDOT (10 μg/μL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect. Animal model: Male Wistar rats (280-320 g) with Rotenone. Dosage: 10 μg/μL. Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes. Result: Increased percentage of time spent in the open arms and in the number of open arms entries.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only