8-M-PDOT

SKU: orb1710523

Description

8-M-PDOT (AH-002) is a potent and selective MT2 receptor agonist with MT1 inhibitory activity. It is utilized in neuroscience research to investigate MT2 receptor-mediated mechanisms, including studies on neuropathic pain models and anxiolytic effects in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 134865-70-6
• MW: 233.31
• Purity: 99.54% (May vary between batches)
• Formula: C₁₄H₁₉NO₂
• SMILES: CCC(=O)NC1CCc2cccc(OC)c2C1
• Target: MT Receptor,Melatonin Receptor
• Solubility: DMSO:50 mg/mL (214.31 mM);10% DMSO+90% Corn Oil:5 mg/mL (21.43 mM)

Bioactivity

• Target IC50:
  MT1 receptor:8.95 (pKi)|MT2 receptor:8.23 (pKi)
• In Vivo:
  Treatment with 8-M-PDOT (10 µg/µL; administered into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) demonstrates an anxiolytic-like effect.
• Animal Research:
  Animal Model: Male Wistar rats (280-320 g) with Rotenone . Dosage: 10 μg/μL. Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MT2 receptor, MT Receptor, MT1 receptor, MTReceptor, 8-Methoxy-2-propionamidotetralin, 8MPDOT, 8-M-PDOT, 8 M PDOT, AH002, AH-002, AH 002

Compound Identifiers

PubChem CID

5170952