8-Chloroadenosine

SKU: orb1306943

Description

8-Chloroadenosine (NSC-354258) is a nucleoside analog metabolized to 8-Chloro-ATP, incorporating into RNA to inhibit synthesis and deplete cellular ATP. It acts as an AMPK agonist, inhibits the mTOR pathway, and demonstrates cytotoxic activity in vitro against various leukemia, myeloma, and solid tumor cell lines, inducing cell cycle arrest.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 34408-14-5
• MW: 301.69
• Purity: 99.84%
• Formula: C₁₀H₁₂ClN₅O₄
• SMILES: ClC=1N(C=2C(N1)=C(N)N=CN2)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O
• Target: AMPK,Autophagy
• Solubility: DMSO:65 mg/mL (215.45 mM)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC354258, NSC-354258, NSC 354258, 5'-AMP-activated protein kinase, 8Chloroadenosine, 8-Chloroadenosine, 8-Cl-Ado, 8 Chloroadenosine

Compound Identifiers

PubChem CID

147569